Obesity and type 2 diabetes are often linked to long-lasting, low-level inflammation in the body. This study looked at blood samples from people with severe obesity to understand whether inflammation differs between those with normal blood sugar, prediabetes, or type 2 diabetes.
The researchers found that some inflammatory proteins were higher in people with type 2 diabetes, but they also discovered that inflammation patterns varied widely from person to person. This means that people with similar weight or blood sugar levels may still have very different biological profiles.
The main message is that metabolic health cannot be understood only by looking at weight or blood sugar. In the future, studying inflammation in the blood may help identify people at higher risk earlier and support more personalized prevention and care.
Original article:
“Inflammatory Proteomic Heterogeneity Beyond Glycemia Status in Severe Obesity” Milito, M; Chiesa, M; Mallia, A; Papaianni, GG; Regalado, J; Tiribelli. C; Bonazza, D; Rosso, N; Palmisano, S; Banfi, C; Giraudi, PJ: Int. J. Mol. Sci. 2026, 27(9), 4152; https://doi.org/10.3390/ijms27094152
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